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U.S. President Donald Trump's administration is considering significantly expanding its travel restrictions by potentially banning citizens of 36 additional countries from entering the United States, according to an internal State Department cable seen by Reuters.

Earlier this month, the Republican president signed a proclamation that banned the entry of citizens from 12 countries, saying the move was needed to protect the United States against "foreign terrorists" and other national security threats.

The directive was part of an immigration crackdown Trump launched this year at the start of his second term, which has included the deportation to El Salvador of hundreds of Venezuelans suspected of being gang members, as well as efforts to deny enrollments of some foreign students from U.S. universities and deport others, according to Reuters.

In an internal diplomatic cable signed by U.S. Secretary of State Marco Rubio, the State Department outlined a dozen concerns about the countries in question and sought corrective action.

President Donald Trump vetoed an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, two U.S. officials told Reuters on Sunday.

"Have the Iranians killed an American yet? No. Until they do we're not even talking about going after the political leadership," said one of the sources, a senior U.S. administration official.

The officials, speaking on condition of anonymity, said top U.S. officials have been in constant communications with Israeli officials in the days since Israel launched a massive attack on Iran in a bid to halt its nuclear program, according to Reuters.

Iran has told mediators Qatar and Oman that it is not open to negotiating a ceasefire while it is under Israeli attack, an official briefed on the communications told Reuters on Sunday, as the two foes launched fresh attacks and raised fears of a wider conflict, Reuters reported ​​​​​.

"The Iranians informed Qatari and Omani mediators that they will only pursue serious negotiations once Iran has completed its response to the Israeli pre-emptive strikes," said the official, who spoke on the condition of anonymity due to the sensitivity of the conflict.

Iran made "clear that it will not negotiate while under attack," the official said.

Israel launched a surprise attack on Iran on Friday morning that wiped out the top echelon of Iran's military command and damaged its nuclear sites, and says the campaign will continue to escalate in coming days, according to Reuters.

Iran has vowed to "open the gates of hell" in retaliation in what has emerged as the biggest ever confrontation between the longstanding enemies.

Israel and Iran kept up their attacks, killing and wounding civilians and raising concern among world leaders at a G7 meeting in Canada this week that the biggest battle between the two old enemies could lead to a broader regional conflict, Reuters reported.

The Iranian death toll in four days of Israeli strikes, carried out with the declared aim of wiping out Iran’s nuclear and ballistic missile programs, had reached at least 224, with 90% of the casualties reported to be civilians, an Iranian health ministry spokesperson said.

Early on Monday, the Israeli military said it had detected more missiles launched from Iran towards Israel.

"At this time, the (Israeli Air Force) is operating to intercept and strike where necessary to eliminate the threat," the Israeli Defence Forces said. Live video footage showed several missiles over Tel Aviv and Reuters witnesses said explosions could be heard there and over Jerusalem, according to Reuters.

At least 10 people in Israel, including children, have been killed so far, according to authorities there.