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A massive fire broke out at the SS Shoe factory at Bhurmeli Tole in Kakadbhitta of Mechinagar-6, Jhapa on Thursday. 

The fire that broke out at the factory of Shyam Tamang has not been taken under control yet. 

A team under the command of DSP of the Area Police Office, Kakadbhitta has been deployed to extinguish the fire. 

The fire engines from Birtamod and Bhadrapur Municipality are helping the police personnel to douse the flame. 

DSP Basanta Pathak of the District Police Office, Jhapa said that the reason behind the fire is yet to be established.

A calm oasis amongst the chaotic streets of Patan, Dhokaima Cafe offers a multi-cuisine menu including fusion dishes inspired by Nepali and Newari cuisines. If you are in the mood for coffee, dessert, beverage, or a full meal – Dhokaima is the place to be.

The cafe is ensconced inside the charming premises of a building that evokes traditional Nepali and European design sensibilities.

And if you happen to be a quiet, bookish type, you can always pick a book or magazine from the cafe bookshelf and enjoy it with a hot cup of coffee.

Also read: House of Eggs: The best eggs in town

Dhokaima also organizes events and meetings.  The cafe has a seminar hall (YalaMaya Kendra) in addition to other rooms for the purpose. It even has a huge parking space–another worry off your shoulders.

Chef’s Special:

-Dhokaima club sandwich

-Grilled trout

-Spicy whole dish

Opening hours: 07:00 AM – 09:00 PM

Location: Patan Dhoka, Lalitpur

Phone/card pay: Accepted

Reservation:  01-5522113

Social media giant Facebook has seen its daily active users (DAUs) drop for the first time in its 18-year history.

Facebook's parent company Meta Networks says DAUs fell to 1.929bn in the three months to the end of December, compared to 1.930bn in the previous quarter.

The firm also warned of slowing revenue growth in the face of competition from rivals like TikTok and YouTube, while advertisers are also cutting spending.

Meta's shares slumped by more than 20% in after-hours trading in New York.

The slide in Meta's share price wiped around $200bn (£147.5bn) off the company's stock market value.

Shares in other social media platforms, including Twitter, Snap and Pinterest, also fell sharply in extended trading.

Chief executive Mark Zuckerberg said the firm's sales growth had been hurt as audiences, especially younger users, had left for rivals. 

Meta, which owns the world's second biggest digital advertising platform after Google, also said it had been hit by privacy changes on Apple's operating system.

The changes have made it harder for brands to target and measure their advertising on Facebook and Instagram and could have an impact "in the order of $10 billion" for this year, according to Meta's chief financial officer Dave Wehner.

Meta's total revenue, the bulk of which comes from advertising sales, rose to $33.67bn in the period, narrowly beating market predictions.

It also forecast revenues of between $27bn to $29bn for the next quarter, which is lower than analysts had expected.

While the company has been making its own investments in video to compete with TikTok -owned by Chinese tech giant ByteDance - it makes less money from those offerings than its traditional Facebook and Instagram feeds.

Mr Zuckerberg said he was confident the investments in video and virtual reality would pay off, as previous bets on mobile advertising and Instagram stories have.

But, he noted, the firm didn't have to contend with a major rival during previous shifts in strategy.

"The teams are executing quite well and the product is growing very quickly," he said. "The thing that is somewhat unique here is that TikTok is so big a competitor already and also continues to grow at quite a fast rate."

Meta on the wane? 

Facebook has always been a platform that grows. 

For every quarter in its existence the global numbers have been in one direction.

Yet in the last few years, growth has stalled in Europe and US. That was masked by rises in users from the rest of the world.

Facebook just isn't as popular with younger people as it was. By its own admission, TikTok is hurting business. 

But there are other reasons too that investors are worried about Meta. 

Meta changed its name because it wanted to focus on the Metaverse. But Meta is nowhere near building a Metaverse yet, it's a pipedream at the moment. 

Instead it is pumping billions of dollars into trying to create one - all because Mark Zuckerberg thinks there's an appetite for it - a huge risk. 

Perhaps the answer to Meta's immediate problems would be to buy TikTok? Well US regulators would never allow that due to anti-competition laws. 

And Facebook is now seen by many in Silicon Valley as a poisonous brand. It's certainly not a cool place to work in the same way it was say ten years ago. 

That makes attracting talent more difficult. 

Meta has some serious problems going forward. This milestone could be just the beginning.

As many as 35 persons were injured in a bus accident in Bansgadhi Municipality-3, Bardiya on Thursday. Of them, two are said to be in critical condition.

The bus (Na 5 Kha 5382) was heading towards Mahendranagar from Kalikot when the incident occurred this morning. Police said that the bus fell some 15 metres down the road.

Sitala Upadhyay (11) of Triveni Rural Minicipality-6 and Omana Upadhyay (69) of Triveni Rural Municipality-7 were critically injured the mishap, the Area Police Office, Motipur said.

Both of them have been sent to the Nepalgunj Medical College in Kohapur, Banke for treatment while others have been sent to the Kausilya Hospital.

Police have arrested a man on the charge of raping a 12-year-old girl in Morang on Wednesday.

The detainee has been identified as Ram Dev Chaudhary (53) of Bansbari, Sundarhairaincha Municipality-5, Morang, DSP Deepak Shrestha, spokesperson at the District Police Office, Morang, said.

According to a preliminary investigation, Chaudhary raped the girl at around 5:30 pm yesterday.

The Area Police Office, Belbari has started the investigation by keeping him in custody.

The girl has been taken to the Dharan-based BP Koirala Institute of Health Sciences for medical check-up and treatment.

The United States is sending 2,000 additional soldiers to Europe and repositioning another 1,000 from Germany to Romania to ensure the “robust defence” of European NATO members, the Pentagon has said, amid the ongoing impasse between Russia and Ukraine, Aljazeera reported.

US Department of Defense spokesman John Kirby told reporters on Wednesday that the troop deployment would take place in the coming days. He said it is separate from, and in addition to, the 8,500 soldiers that the Pentagon put on heightened alert last week.

Kirby stressed, however, that the US forces are not going to be deployed to Ukraine, which is not a NATO member.

“These movements are unmistakable signals to the world that we stand ready to reassure our NATO allies and deter and defend against any aggression,” he said.

The White House announced Wednesday that 1,700 soldiers would deploy from Fort Bragg in the US state of North Carolina to Poland and another 300 would be sent from the base to Germany.

The Russian military has been amassing troops near the country’s border with Ukraine, sparking a diplomatic crisis and heightening US and European fears that Moscow may be preparing for an imminent invasion of its neighbour.

Russia has denied it is planning to invade, but has vehemently opposed Ukraine’s efforts to join NATO. Moscow also wants security guaranteesthat the US-led alliance will stop its expansion into former Soviet republics, but Washington and NATO have rejected the demand as a “non-starter”.

Pentagon confirms proposal to Russia

On Wednesday, Kirby confirmed media reports that Washington offered to allow Moscow to confirm there are no Tomahawk cruise missiles at bases in Romania and Poland – on the condition that Russia reciprocates with its own “transparency measures”.

Spanish newspaper El Pais had published US documents outlining the proposals earlier in the day.

Kirby said while the US did not make the documents public, they illustrate that Washington is serious about resolving the crisis diplomatically.

“If Russia actually wants to negotiate a solution as it claims it does, this document certainly makes clear that there is a path forward to do so,” he said.

The US delivered written responses addressing Russia’s security concerns last week, but senior Russian officials have responded with wariness to Washington’s position.

“It is already clear that fundamental Russian concerns ended up being ignored,” Russian President Vladimir Putin said on Tuesday – his first comments on the ongoing crisis in more than a month.

Putin said the Kremlin was studying a response from the US and NATO but said the replies had been far from adequate. He accused the US of using Ukraine as a “tool” in its efforts to contain Russia, but said it was still possible to find a solution to end the crisis.

“I hope that we will eventually find a solution, although we realise that it’s not going to be easy,” Putin said.

Kirby also told reporters on Wednesday that war can be avoided. “The Department of Defense will continue to support diplomatic efforts led by the White House and the State Department to press for a resolution. We do not believe conflict is inevitable,” he said.

Russia responds

Moscow denounced the US move later on Wednesday, calling it “destructive”.

The US deployments are “destructive steps, which increase military tension and reduce scope for political decision,” Russian Deputy Foreign Minister Alexander Grushko told the Interfax news agency.

But US State Department spokesperson Ned Price rejected Moscow’s assertion that Washington is escalating tensions by sending additional troops to Europe, accusing Russia of attempting to turn “reality upside down”.

“These are not permanent moves; they are precisely in response to the current security environment in light of this increasingly threatening behaviour by the Russian Federation,” Price told reporters on Wednesday.

US President Joe Biden said the decision was “totally consistent” with what he had told Putin. “As long as he is acting aggressively we’re going to make sure we can reassure our NATO allies and Eastern Europe that we’re there,” Biden told a CNN reporter.

NATO welcomes US decision

NATO Secretary-General Jens Stoltenberg welcomed the US decision to send additional troops to Europe.

“This is a powerful signal of US commitment, and comes on top of other recent US contributions to our shared security,” Stoltenberg said in a statement on Wednesday.

US Republican Senator Lindsey Graham also lauded the troop deployment.

“I completely support the Biden Administration’s decision to send more US troops to bolster NATO allies in the face of Russian aggression,” Graham wrote on Twitter. “It is imperative that NATO meet the moment and that we stand firmly against Putin’s efforts to divide the alliance.”

But other Republicans who favour a more reserved foreign policy denounced Biden’s move.

“I am strongly opposed to President Biden’s decision to send American troops to Eastern Europe to defend countries that should defend themselves, potentially involving us in another conflict after just ending a 20-year war,” Republican Senator Mike Braun said, referring to the Afghanistan conflict.

Al Jazeera correspondent Kimberly Halkett underscored many Americans’ “fatigue” of wars.

“In the United States, there certainly is a lot of fatigue surrounding conflict in general, particularly given the fact that there was that messy withdrawal of US troops from Afghanistan just a few months back… the United States is just as a population tired after a generation of war,” Halkett said.

The world's first "human challenge" trial in which volunteers were deliberately exposed to COVID-19 to advance research into the disease was found to be safe in healthy young adults, leaders of the study said on Wednesday.

The data supports the safety of this model and lays the groundwork for future studies to test new vaccines and medicines against COVID-19 using this kind of trial by the end of this year, the team added.

Open Orphan (ORPH.L) is running the project, launched last February, with Imperial College London, Britain's vaccines task force and Orphan's clinical company  hVIVO. 

Scientists have used human challenge trials for decades to learn more about diseases such as malaria, flu, typhoid and cholera, and to develop treatments and vaccines against them.

The Imperial trial exposed 36 healthy male and female volunteers aged 18-29 years to the original SARS-CoV-2 strain of the virus and monitored them in a quarantined setting. They will be followed up for 12 months after discharge.

No serious adverse events occurred, and the human challenge study model was shown to be safe and well tolerated in healthy young adults, the company said.

"People in this age group are believed to be major drivers of the pandemic and these studies, which are representative of mild infection, allow detailed investigation of the factors responsible for infection and pandemic spread," said Chris Chiu, chief investigator on the trial and professor of infectious diseases at Imperial.

The Imperial researchers said they now planned to start a similar study using the Delta variant, and will share their framework around the globe to allow similar research.

That could provide a crucial route to testing new vaccines, antivirals and diagnostics against COVID-19 more quickly, particularly if transmission rates fall in the real world.

Imperial said it could start tests like this using human challenge trials by the end of 2022.

In April, Oxford University launched another human challenge trial which sought to reinfect people to deepen understanding about immunity.

CLINICAL INSIGHTS

The results of the Imperial study, published on a pre-print server and yet to be peer reviewed, also provide some clinical insights that could inform public health policies.

Researchers found that symptoms start to develop on average about two days after contact with the virus, Imperial said, which is earlier than the widely held view that the virus has an incubation period of around five days.

The infection first appears in the throat; infectious virus peaks about five days into infection, which is also when the most significant symptoms are usually noticed, the researchers said. At that stage, the virus is significantly more abundant in the nose than the throat.

They also found that rapid lateral flow tests were a reliable indicator of whether infectious virus was present and therefore the person was likely to be able to transmit the virus. Most people had live virus in their nose for an average of 6.5 days, they said.

Eighteen volunteers became infected, 16 of whom went on to develop mild-to-moderate cold-like symptoms, including a stuffy or runny nose, sneezing, and a sore throat, Imperial said.

Some experienced headaches, muscle/joint aches, tiredness and fever. None developed serious symptoms.

Thirteen infected volunteers temporarily lost their sense of smell, but this returned within 90 days in all but three participants – the remainder continue to show improvement after three months.

There were no changes seen in their lungs, or any serious adverse events. Only one person had any lingering symptoms by six months - a slightly reduced sense of smell which was improving.

The trial used the lowest dose necessary to infect people, although the team said it was comparable to real-world infections.

The scientists will now study other elements from the trial, including investigating why the 16 of the 34 participants in the final analysis did not get infected despite exposure. Some had detectable virus in their nose but did not go on to test positive twice on PCR tests, the threshold the team used for confirmed infection.

CPN-UML has decided to take action against those involved in betraying the party in the National Assembly elections.

Publicity Department Chief Prithvi Subba Gurung said that a Secretariat meeting of the party held on Wednesday decided to take action against those involved in betraying the party National Assembly elections.

He said that the meeting has directed the party leaders and cadres to start preparations for the local level elections.

Similarly, the party has decided to hold the province conventions after the local elections and to district conventions before the elections.

“The party has decided to organise gatherings of leaders and cadres at the central and province level focusing on the local elections and also decided to hold the national conventions of the people’s organisations on the scheduled date,” he said.