Manchester City suffered a rare Champions League defeat at the Etihad Stadium on Tuesday as Bundesliga side Bayer Leverkusen claimed a stunning 2-0 victory to end the hosts' 23-game unbeaten home run in the competition's group or league stage, Reuters reported.

The loss spoiled Pep Guardiola's 100th Champions League match as City manager and left the Premier League side provisionally sixth on 10 points after five games. Alejandro Grimaldo and Patrik Schick scored for Leverkusen, who are 13th.

Guardiola rested most of his regular starters for the first half with 10 changes to his team and the risky move backfired, according to Reuters.